Triumvira Immunologics Presents Updates on Clinical Trials

AUSTIN, Texas and HAMILTON, ON and SAN DIEGO — Triumvira Immunologics, a clinical-stage company developing novel, targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors, recently presented an abstract at the 2025 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium, which was held in San Francisco, California, from January 23-25, 2025. The company showcased updated clinical data from its ongoing Phase I/II TACTIC-3 study investigating the safety and efficacy of autologous TAC-T cells in subjects with Claudin 18.2+ advanced solid tumors (TACTIC-3 / NCT05862324).

The poster presentation, titled "A Phase 1/2 Study Evaluating the Safety and Efficacy of Autologous TAC-T Cells in Subjects with Claudin 18.2+ Advanced Solid Tumors," provided an in-depth look at interim results from the Phase I study. Key highlights included:

HOUSTON and SAN DIEGO – Nov. 11, 2024 — Triumvira Immunologics announced that preliminary results from its Phase I/II clinical trial TACTIC-3 (NCT05862324) investigating the safety and efficacy of autologous TAC01-CLDN18.2 in subjects with Claudin 18.2 positive solid tumors, were presented in a poster and an oral presentation at the 39th Society for Immunotherapy of Cancer Annual Meeting, held November 6-10 in Houston.

Ecaterina E. Dumbrava, MD, Assistant Professor in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center, presented promising preliminary clinical data from TACTIC-3 showing the positive safety profile and encouraging therapeutic potential of TAC01-CLDN18.2 at lower dosages, even among patients who have undergone multiple prior treatments.

SAN DIEGO and AUSTIN, TX and HAMILTON, ON – Oct 30, 2024 — Triumvira Immunologics announced that Dr. Ecaterina E. Dumbrava will present a late-breaking abstract at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) 2024, held from November 6-10, 2024, in Houston, Texas.

The oral presentation will highlight interim data from Triumvira’s ongoing Phase 1/2 study, TACTIC-3 clinical trial, which is investigating the safety and efficacy of TAC101-CLDN18.2, a novel T cell therapy targeting Claudin 18.2+ advanced solid tumors. The therapy leverages Triumvira’s proprietary T cell Antigen Coupler (TAC) technology, a unique platform that activates natural T cell functions to combat solid tumors effectively and safely.

SAN DIEGO and AUSTIN, TX and HAMILTON, ON – Feb. 5, 2024 — Triumvira Immunologics announced the publication of a peer-reviewed article titled “Preclinical development of T cells engineered to express a T cell antigen coupler (TAC) targeting Claudin 18.2-positive solid tumors” in Cancer Immunology Research. The article details the preclinical pharmacology and safety of TAC01-CLDN18.2, a novel autologous T cell therapy targeting Claudin 18.2 for the treatment of solid tumors. TAC01-CLDN18.2 is currently the subject of a clinical Phase I/II study (TACTIC-3, NCT05862324).

“Our findings highlight the unique advantages of TAC01-CLDN18.2, which is designed to target and eliminate tumors with high specificity while minimizing the risk of adverse events that are commonly associated with T cell and other therapies,” said Andreas Bader, Ph.D., Consulting Chief Scientific Officer of Triumvira Immunologics.

Austin, TX, Hamilton, ON and South San Francisco, CA – Dec. 19, 2023 — Triumvira Immunologics announced that it will present two abstracts at the 2024 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium in San Francisco, California, from January 18-20, 2024. The company will showcase clinical data from its ongoing Phase I/II studies investigating the safety and efficacy of autologous TAC-T cells targeting human epidermal growth factor receptor 2 (HER2) and Claudin 18.2.

The technology behind TAC01-HER2 and TAC01-CLDN18.2 stands as an innovative cell-based therapeutic modality, harnessing genetically engineered T cells derived autologously. These T cells are equipped with a T-cell Antigen Coupler (TAC) rationally designed to specifically recognize HER2 or CLDN18.2 within tumor cells.

AUSTIN, Texas and HAMILTON, ON and SOUTH SAN FRANCISCO, Calif., July 20, 2023 — Triumvira Immunologics announced the strengthening of its leadership team with the appointments of Mr. Robert Williamson as President, Chief Operating Officer; Mr. Jeffrey Erickson as VP of Business Development; and Mr. Chris Murray as VP of Human Resources.

“The appointment of Robert as our President and Director, Chris as our VP of Human Resources, and the addition of Jeffrey to the team will be instrumental in our efforts to expand our team of experts and advance our T cell Antigen Coupler (TAC) technology and lead assets, including our novel autologous cell therapy TAC100-HER2, to late-stage clinical development,” said Paul Lammers, M.D., M.Sc., Chief Executive Officer of Triumvira.